The availability of drug by liposomal drug delivery
نویسندگان
چکیده
منابع مشابه
Imaging of liposomal drug delivery systems by atomic force microscopy
Over the past four decades, the research focused in the development of new liposomal drug delivery systems exponentially grew as a result of their proven efficacy in carrying pharmacological active molecules to target specific sites. In fact, the drug loading into liposomes both increases the drug’s bioavailability through the prevention of unfavourable chemical reactions triggered by enzymatic...
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Encapsulating cytostatics into lipid vesicles, i.e. liposomes, improves tumour drug accumulation and reduce adverse effects. Liposomal doxorubicin (DXR) has been used in the treatment of a variety of cancers and may also be suitable for combining with other treatment modalities. By modulating liposomal membranes, liposomes can be made ultrasound (US) sensitive releasing encapsulated drug in tum...
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Almost from the time of their rediscovery in the 60's and the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications in humans and animals. Several commercial liposome-based drugs have already been discovered, registered and introduced with great succ...
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Liposomes have been widely investigated since 1970 as drug carriers for improving the delivery of therapeutic agents to specific sites in the body. As a result, numerous improvements have been made, thus making this technology potentially useful for the treatment of certain diseases in the clinics. The success of liposomes as drug carriers has been reflected in a number of liposome-based formul...
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Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to M...
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ژورنال
عنوان ژورنال: Investigational New Drugs
سال: 2018
ISSN: 0167-6997,1573-0646
DOI: 10.1007/s10637-018-0708-4